Examples: Data from clinical studies

• Alzheimer’s. Mayieux, 1998. 81% prevalence.

• Tests: Sensit Specif

  • APOE epsilon 4 allele .928 .545
  • Clinical diagnosis .645 .682
  • Criterion: post mortem pathology

• Correlations between the tests

  • When Alzheimer’s present .073
  • When Alzheimer’s absent .057
  • Overall .186

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