Example: PSA and DRE for Prostate Cancer (Cooner, 1990)

• Case control study (50%)

• Prevalence ~3.5%

• Tests Sensitivity Specificity

  • PSA .802 .607
  • DRE .772 .553

• Criterion: Biopsy

• Correlations between the tests

  • When prostate cancer present .162
  • When prostate cancer absent .000

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