Users' Guides: Harm
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Are the results valid?
What are the results?
Will the results help me in patient care?
Understanding Strength of Association

Are the results valid?

Except for the exposure under study, were the compared groups similar to each other?
Were the outcomes and exposures measured in the same way in the groups being compared?
Was follow-up sufficiently long and complete?
Is the temporal relationship correct?
Is there a dose-response gradient ?

What are the results?

How strong is the association between exposure and outcome?
How precise is the estimate of risk?

Will the results help me in patient care?

Are the results applicable to my patients?
What is the magnitude of the risk?
Should I attempt to stop the exposure?

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