Users' Guide: Therapy/Prevention
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Are the results valid?
What are the results?
Will the results help patient care?
Are patient's values satisfied by the regimen?

Are the results valid?
Was the assignment of patients to treatment randomized?
Were all patients who entered the trial accounted for and attributed at its conclusion?
Were patients, their clinicians and study personnel kept 'blind' to treatment received?
Were the groups similar at the start of the trial?
Aside from the experimental intervention, were the groups treated equally?

What are the results?
How large is the treatment effect?
How precise is the estimate of the treatment effect?

Will the results help me in my patient care?
Can the results be applied to my patients?
Were all clinically relevant outcomes considered?
Are the benefits worth the harms and costs?

Are your patient's values and preferences satisfied by the regimen and its consequences?
Do your patient and you have a clear assessment of their values and preferences?
Are they met by this regimen and its consequences?

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